The cell cycle regulator ecdysoneless cooperates with H-Ras to promote oncogenic transformation of human mammary epithelial cells

The mammalian ortholog of Drosophila ecdysoneless (Ecd) gene product regulates Rb-E2F interaction and is required for cell cycle progression. Ecd is overexpressed in breast cancer and its overexpression predicts shorter survival in patients with ErbB2-positive tumors. Here, we demonstrate Ecd knock...

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Udgivet i:Cell Cycle
Main Authors: Bele, Aditya, Mirza, Sameer, Zhang, Ying, Ahmad Mir, Riyaz, Lin, Simon, Kim, Jun Hyun, Gurumurthy, Channabasavaiah Basavaraju, West, William, Qiu, Fang, Band, Hamid, Band, Vimla
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614725/
https://ncbi.nlm.nih.gov/pubmed/25616580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1006982
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