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Acute effects of phenylbutyrate on glutamine, branched‐chain amino acid and protein metabolism in skeletal muscles of rats

Phenylbutyrate (PB) acts as chemical chaperone and histone deacetylase inhibitor, which is used to decrease ammonia in urea cycle disorders and has been investigated for use in the treatment of a number of lethal illnesses. We performed in vivo and in vitro experiments to examine the effects of PB o...

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Опубликовано в: :Int J Exp Pathol
Главные авторы: Holecek, Milan, Vodenicarovova, Melita, Siman, Pavel
Формат: Artigo
Язык:Inglês
Опубликовано: John Wiley and Sons Inc. 2017
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573773/
https://ncbi.nlm.nih.gov/pubmed/28621016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/iep.12231
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