Exposure–response relationship of ramucirumab in patients with advanced second-line colorectal cancer: exploratory analysis of the RAISE trial

PURPOSE: To characterize ramucirumab exposure–response relationships for efficacy and safety in patients with metastatic colorectal cancer (mCRC) using data from the RAISE study. METHODS: Sparse pharmacokinetic samples were collected; a population pharmacokinetic analysis was conducted. Univariate a...

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Publicado en:Cancer Chemother Pharmacol
Autores principales: Cohn, Allen Lee, Yoshino, Takayuki, Heinemann, Volker, Obermannova, Radka, Bodoky, György, Prausová, Jana, Garcia-Carbonero, Rocio, Ciuleanu, Tudor, Garcia-Alfonso, Pilar, Portnoy, David C., Van Cutsem, Eric, Yamazaki, Kentaro, Clingan, Philip R., Polikoff, Jonathon, Lonardi, Sara, O’Brien, Lisa M., Gao, Ling, Yang, Ling, Ferry, David, Nasroulah, Federico, Tabernero, Josep
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer Berlin Heidelberg 2017
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573752/
https://ncbi.nlm.nih.gov/pubmed/28744667
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-017-3380-z
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