Therapeutic concentrations of digitoxin inhibit endothelial focal adhesion kinase and angiogenesis induced by different growth factors

BACKGROUND AND PURPOSE: Cardiac glycosides are Na(+)/K(+)‐ATPases inhibitors used to treat congestive heart failure and cardiac arrhythmias. Epidemiological studies indicate that patients on digitalis therapy are more protected from cancer. Evidence of a selective cytotoxicity against cancer cells h...

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Publicat a:Br J Pharmacol
Autors principals: Trenti, Annalisa, Zulato, Elisabetta, Pasqualini, Lorenza, Indraccolo, Stefano, Bolego, Chiara, Trevisi, Lucia
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2017
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573418/
https://ncbi.nlm.nih.gov/pubmed/28688145
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13944
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