Pepcan-12 (RVD-hemopressin) is a CB2 receptor positive allosteric modulator constitutively secreted by adrenals and in liver upon tissue damage

Pepcan-12 (RVD-hemopressin; RVDPVNFKLLSH) is the major peptide of a family of endogenous peptide endocannabinoids (pepcans) shown to act as negative allosteric modulators (NAM) of cannabinoid CB1 receptors. Noradrenergic neurons have been identified to be a specific site of pepcan production. Howeve...

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Pubblicato in:Sci Rep
Autori principali: Petrucci, Vanessa, Chicca, Andrea, Glasmacher, Sandra, Paloczi, Janos, Cao, Zongxian, Pacher, Pal, Gertsch, Jürg
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573408/
https://ncbi.nlm.nih.gov/pubmed/28842619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09808-8
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