Results from (11)C-metformin-PET scans, tissue analysis and cellular drug-sensitivity assays questions the view that biguanides affects tumor respiration directly

The anti-diabetic biguanide drugs metformin (METF) and phenformin (PHEN) may have anti-cancer effects. Biguanides suppress plasma growth factors, but nonetheless, the view that these mitochondrial inhibitors accumulate in tumor tissue to an extent that leads to severe energetic stress or alleviation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Iversen, Ane B., Horsman, Michael R., Jakobsen, Steen, Jensen, Jonas B., Garm, Christian, Jessen, Niels, Breining, Peter, Frøkiær, Jørgen, Busk, Morten
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573362/
https://ncbi.nlm.nih.gov/pubmed/28842630
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10010-z
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