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The Levinthal Problem in Amyloid Aggregation: Sampling of a Flat Reaction Space

The formation of amyloid fibrils has been associated with many neurodegenerative disorders, yet the mechanism of aggregation remains elusive, partly because aggregation timescales are too long to probe with atomistic simulations. A microscopic theory of fibril elongation was recently developed that...

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Bibliografiska uppgifter
I publikationen:J Phys Chem B
Huvudupphovsmän: Jia, Zhiguang, Beugelsdijk, Alex, Chen, Jianhan, Schmit, Jeremy D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5573152/
https://ncbi.nlm.nih.gov/pubmed/28129689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jpcb.7b00253
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