A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNA(Leu(UUR))

Several mitochondrial tRNA mutations have been associated with hypertension, but their pathophysiology remains poorly understood. In this report, we identified a novel homoplasmic 3253T→C mutation in the mitochondrial tRNA(Leu(UUR)) gene in a Han Chinese family with maternally inherited hypertension...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Zhou, Mi, Wang, Meng, Xue, Ling, Lin, Zhi, He, Qiufen, Shi, Wenwen, Chen, Yaru, Jin, Xiaofen, Li, Haiying, Jiang, Pingping, Guan, Min-Xin
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
RNA
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572913/
https://ncbi.nlm.nih.gov/pubmed/28679533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787028
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