A hypertension-associated mitochondrial DNA mutation alters the tertiary interaction and function of tRNA(Leu(UUR))

Several mitochondrial tRNA mutations have been associated with hypertension, but their pathophysiology remains poorly understood. In this report, we identified a novel homoplasmic 3253T→C mutation in the mitochondrial tRNA(Leu(UUR)) gene in a Han Chinese family with maternally inherited hypertension...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Zhou, Mi, Wang, Meng, Xue, Ling, Lin, Zhi, He, Qiufen, Shi, Wenwen, Chen, Yaru, Jin, Xiaofen, Li, Haiying, Jiang, Pingping, Guan, Min-Xin
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572913/
https://ncbi.nlm.nih.gov/pubmed/28679533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.787028
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