Hsp70's RNA-binding and mRNA-stabilizing activities are independent of its protein chaperone functions

Hsp70 is a protein chaperone that prevents protein aggregation and aids protein folding by binding to hydrophobic peptide domains through a reversible mechanism directed by an ATPase cycle. However, Hsp70 also binds U-rich RNA including some AU-rich elements (AREs) that regulate the decay kinetics o...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Kishor, Aparna, White, Elizabeth J. F., Matsangos, Aerielle E., Yan, Zisui, Tandukar, Bishal, Wilson, Gerald M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
RNA
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572911/
https://ncbi.nlm.nih.gov/pubmed/28679534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.785394
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg