Inhibition of the reactions catalysed by a type I topoisomerase and catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of the catenating reaction.

A catenating enzyme and a type I topoisomerase were purified from Trypanosoma cruzi. We investigated the inhibitory effect of DNA-intercalating drugs on topoisomerisations catalysed by these enzymes. Inhibition of catenation was detected by electrophoretic analysis in neutral agarose gels. However,...

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Dettagli Bibliografici
Pubblicato in:EMBO J
Autori principali: Douc-Rasy, S, Kayser, A, Riou, G F
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 1984
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC557290/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/6323159/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1984.tb01754.x
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