Inhibition of the reactions catalysed by a type I topoisomerase and catenating enzyme of Trypanosoma cruzi by DNA-intercalating drugs. Preferential inhibition of the catenating reaction.

A catenating enzyme and a type I topoisomerase were purified from Trypanosoma cruzi. We investigated the inhibitory effect of DNA-intercalating drugs on topoisomerisations catalysed by these enzymes. Inhibition of catenation was detected by electrophoretic analysis in neutral agarose gels. However,...

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Autori principali: Douc-Rasy, S, Kayser, A, Riou, G F
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1984
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC557290/
https://ncbi.nlm.nih.gov/pubmed/6323159
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