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Therapeutic Antibodies to Ganglioside GD2 Evolved from Highly Selective Germline Antibodies

Antibodies play a crucial role in host defense and are indispensable research tools, diagnostics, and therapeutics. Antibody generation involves binding of genomically encoded germline antibodies followed by somatic hypermutation and in vivo selection to obtain antibodies with high affinity and sele...

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Detalhes bibliográficos
Publicado no:Cell Rep
Main Authors: Sterner, Eric, Peach, Megan L., Nicklaus, Marc C., Gildersleeve, Jeffrey C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572838/
https://ncbi.nlm.nih.gov/pubmed/28813678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2017.07.050
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