Alteration of serum lipid profile, SRB1 loss, and impaired Nrf2 activation in CDKL5 disorder

CDKL5 mutation is associated with an atypical Rett syndrome (RTT) variant. Recently, cholesterol homeostasis perturbation and oxidative-mediated loss of the high-density lipoprotein receptor SRB1 in typical RTT have been suggested. Here, we demonstrate an altered lipid serum profile also in CDKL5 pa...

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Detalhes bibliográficos
Publicado no:Free Radic Biol Med
Main Authors: Pecorelli, Alessandra, Belmonte, Giuseppe, Meloni, Ilaria, Cervellati, Franco, Gardi, Concetta, Sticozzi, Claudia, De Felice, Claudio, Signorini, Cinzia, Cortelazzo, Alessio, Leoncini, Silvia, Ciccoli, Lucia, Renieri, Alessandra, Forman, Henry Jay, Hayek, Joussef, Valacchi, Giuseppe
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572621/
https://ncbi.nlm.nih.gov/pubmed/26006105
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2015.05.010
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