CDYL suppresses epileptogenesis in mice through repression of axonal Nav1.6 sodium channel expression

Impairment of intrinsic plasticity is involved in a range of neurological disorders such as epilepsy. However, how intrinsic excitability is regulated is still not fully understood. Here we report that the epigenetic factor Chromodomain Y-like (CDYL) protein is a critical regulator of the initiation...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Liu, Yongqing, Lai, Shirong, Ma, Weining, Ke, Wei, Zhang, Chan, Liu, Shumeng, Zhang, Yu, Pei, Fei, Li, Shaoyi, Yi, Ming, Shu, Yousheng, Shang, Yongfeng, Liang, Jing, Huang, Zhuo
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5572458/
https://ncbi.nlm.nih.gov/pubmed/28842554
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-00368-z
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