Bactericidal and Sterilizing Activity of a Novel Regimen with Bedaquiline, Pretomanid, Moxifloxacin, and Pyrazinamide in a Murine Model of Tuberculosis

New regimens based on 2 or more novel agents are sought to shorten or to simplify treatment of tuberculosis (TB), including drug-resistant forms. Prior studies showed that the novel combinations of bedaquiline (BDQ) plus pretomanid (PMD) plus pyrazinamide (PZA) and PMD plus moxifloxacin (MXF) plus P...

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Li, Si-Yang, Tasneen, Rokeya, Tyagi, Sandeep, Soni, Heena, Converse, Paul J., Mdluli, Khisimuzi, Nuermberger, Eric L.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2017
Témata:
Experimental Therapeutics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571308/
https://ncbi.nlm.nih.gov/pubmed/28630203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00913-17
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