Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways

The aim of this study was to investigate the effect of quercetin on hepatic fibrosis, a characteristic response to acute or chronic liver injury. Mice were randomized to bile duct ligation (BDL) or carbon tetrachloride (CCl(4)) cirrhosis models. Quercetin (100 mg/kg or 200 mg/kg daily) was administe...

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Gepubliceerd in:Sci Rep
Hoofdauteurs: Wu, Liwei, Zhang, Qinghui, Mo, Wenhui, Feng, Jiao, Li, Sainan, Li, Jingjing, Liu, Tong, Xu, Shizan, Wang, Wenwen, Lu, Xiya, Yu, Qiang, Chen, Kan, Xia, Yujing, Lu, Jie, Xu, Ling, Zhou, Yingqun, Fan, Xiaoming, Guo, Chuanyong
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group UK 2017
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571156/
https://ncbi.nlm.nih.gov/pubmed/28839277
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09673-5
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