Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit

Influenza virus uses a unique mechanism to initiate viral transcription named cap-snatching. The PB2 subunit of the viral heterotrimeric RNA polymerase binds the cap structure of cellular pre-mRNA to promote its cleavage by the PA subunit. The resulting 11–13 capped oligomer is used by the PB1 polym...

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Publicado no:Sci Rep
Main Authors: Ma, Xiaolei, Xie, Lili, Wartchow, Charles, Warne, Robert, Xu, Yongjin, Rivkin, Alexey, Tully, David, Shia, Steven, Uehara, Kyoko, Baldwin, Dianna M., Muiru, Gladys, Zhong, Weidong, Zaror, Isabel, Bussiere, Dirksen E., Leonard, Vincent H. J.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5571044/
https://ncbi.nlm.nih.gov/pubmed/28839261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09538-x
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