Structural insight into the essential PB1–PB2 subunit contact of the influenza virus RNA polymerase

Influenza virus RNA-dependent RNA polymerase is a multi-functional heterotrimer, which uses a ‘cap-snatching' mechanism to produce viral mRNA. Host cell mRNA is cleaved to yield a cap-bearing oligonucleotide, which can be extended using viral genomic RNA as a template. The cap-binding and endon...

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Detalhes bibliográficos
Main Authors: Sugiyama, Kanako, Obayashi, Eiji, Kawaguchi, Atsushi, Suzuki, Yukari, Tame, Jeremy R H, Nagata, Kyosuke, Park, Sam-Yong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2699363/
https://ncbi.nlm.nih.gov/pubmed/19461581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2009.138
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