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Indole-based perenosins as highly potent HCl transporters and potential anti-cancer agents

Prodigiosin is one of the most potent anion transporters in lipid bilayer membranes reported to date. Inspired by the structure of this natural product, we have recently designed and synthesised a new class of H(+)/Cl(−) cotransporters named ‘perenosins’. Here we report a new library of indole-based...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jowett, Laura A., Howe, Ethan N. W., Soto-Cerrato, Vanessa, Van Rossom, Wim, Pérez-Tomás, Ricardo, Gale, Philip A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570892/
https://ncbi.nlm.nih.gov/pubmed/28839192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09645-9
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