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SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity
Lipotoxicity induced by saturated fatty acids (SFAs) plays a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be fully elucidated. SIRT3 is an NAD(+)-dependent deacetylase primarily located inside mitochondria. In this study, we...
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| 出版年: | Hepatology |
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| 主要な著者: | , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570642/ https://ncbi.nlm.nih.gov/pubmed/28437863 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29229 |
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