Tert-butylhydroquinone (tBHQ) protects hepatocytes against lipotoxicity via inducing autophagy independently of Nrf2 activation

Saturated fatty acids (SFAs) induce hepatocyte cell death, wherein oxidative stress is mechanistically involved. Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a master transcriptional regulator of cellular antioxidant defense enzymes. Therefore, Nrf2 activation is regarded as an effective st...

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Bibliographische Detailangaben
Hauptverfasser: Li, Songtao, Li, Jiaxin, Shen, Chen, Zhang, Ximei, Sun, Shan, Cho, Michael, Sun, Changhao, Song, Zhenyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3884638/
https://ncbi.nlm.nih.gov/pubmed/24055888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2013.09.004
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