SIRT3 Acts As a Negative Regulator of Autophagy Dictating Hepatocyte Susceptibility to Lipotoxicity

Lipotoxicity induced by saturated fatty acids (SFAs) plays a central role in the pathogenesis of non-alcoholic fatty liver disease (NAFLD); however, the exact mechanism(s) remain to be fully elucidated. SIRT3 is an NAD(+)-dependent deacetylase primarily located inside mitochondria. In this study, we...

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Veröffentlicht in:Hepatology
Hauptverfasser: Li, Songtao, Dou, Xiaobing, Ning, Hua, Song, Qing, Wei, Wei, Zhang, Ximei, Shen, Chen, Li, Jiaxin, Sun, Changhao, Song, Zhenyuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570642/
https://ncbi.nlm.nih.gov/pubmed/28437863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.29229
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