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In Vivo Base Editing of PCSK9 as a Therapeutic Alternative to Genome Editing
OBJECTIVE: High-efficiency genome editing to disrupt therapeutic target genes such as PCSK9 has been demonstrated in preclinical animal models, but there are safety concerns due to the unpredictable nature of cellular repair of double-strand breaks, as well as off-target mutagenesis. Moreover, preci...
Shranjeno v:
| izdano v: | Arterioscler Thromb Vasc Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2017
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5570639/ https://ncbi.nlm.nih.gov/pubmed/28751571 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.117.309881 |
| Oznake: |
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