Effect of HPV E6/E7 siRNA with Chemotherapeutic Agents on the Regulation of TP53/E2F Dynamic Behavior for Cell Fate Decisions

Toxicity and resistance remain major challenges for advanced or recurrent cervical cancer therapies, as treatment requires high doses of chemotherapeutic agents. Restoration of TP53 and hypophosphorylated-retinoblastoma (pRB) proteins by human papillomavirus (HPV) E6/E7 siRNA sensitizes HPV-positive...

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Detalhes bibliográficos
Publicado no:Neoplasia
Main Authors: Rajasekaran, Nirmal, Jung, Hun Soon, Bae, Soo Hyeon, Chelakkot, Chaithanya, Hong, Sungyoul, Choi, Jong-Sun, Yim, Dong-Seok, Oh, Yu-Kyoung, Choi, Yoon-La, Shin, Young Kee
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2017
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Original article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570578/
https://ncbi.nlm.nih.gov/pubmed/28843398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.07.005
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