Human Papillomavirus E6/E7-Specific siRNA Potentiates the Effect of Radiotherapy for Cervical Cancer in Vitro and in Vivo

The functional inactivation of TP53 and Rb tumor suppressor proteins by the HPV-derived E6 and E7 oncoproteins is likely an important step in cervical carcinogenesis. We have previously shown siRNA technology to selectively silence both E6/E7 oncogenes and demonstrated that the synthetic siRNAs coul...

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Vydáno v:Int J Mol Sci
Hlavní autoři: Jung, Hun Soon, Rajasekaran, Nirmal, Song, Sang Yong, Kim, Young Deug, Hong, Sungyoul, Choi, Hyuck Jae, Kim, Young Seok, Choi, Jong-Sun, Choi, Yoon-La, Shin, Young Kee
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2015
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4490442/
https://ncbi.nlm.nih.gov/pubmed/26035754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms160612243
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