Single Cell Methylomes Identify Neuronal Subtypes and Regulatory Elements in Mammalian Cortex

The mammalian brain contains diverse neuronal types, yet we lack single-cell epigenomic assays able to identify and characterize them. DNA methylation is a stable epigenetic mark that distinguishes cell types and marks regulatory elements. We generated >6,000 methylomes from single neuronal nucle...

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Gepubliceerd in:Science
Hoofdauteurs: Luo, Chongyuan, Keown, Christopher L., Kurihara, Laurie, Zhou, Jingtian, He, Yupeng, Li, Junhao, Castanon, Rosa, Lucero, Jacinta, Nery, Joseph R., Sandoval, Justin P., Bui, Brian, Sejnowski, Terrence J., Harkins, Timothy T., Mukamel, Eran A., Behrens, M. Margarita, Ecker, Joseph R.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570439/
https://ncbi.nlm.nih.gov/pubmed/28798132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aan3351
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