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Cardiac transcriptome profiling of diabetic Akita mice using microarray and next generation sequencing

Although diabetes mellitus (DM) causes cardiomyopathy and exacerbates heart failure, the underlying molecular mechanisms for diabetic cardiomyopathy/heart failure are poorly understood. Insulin2 mutant (Ins2(+/-)) Akita is a mouse model of T1DM, which manifests cardiac dysfunction. However, molecula...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Kesherwani, Varun, Shahshahan, Hamid R., Mishra, Paras K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570368/
https://ncbi.nlm.nih.gov/pubmed/28837672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182828
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