Frequent AKT1(E17K) mutations in skull base meningiomas are associated with mTOR and ERK1/2 activation and reduced time to tumor recurrence

BACKGROUND. Skull base meningiomas are considered to be difficult for surgical treatment. We wondered whether genetic alterations recently identified in benign non-NF2-mutated World Health Organization (WHO) grade I meningiomas are related to clinical features of skull base meningiomas and whether d...

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Vydáno v:Neuro Oncol
Hlavní autoři: Yesilöz, Ümmügülsüm, Kirches, Elmar, Hartmann, Christian, Scholz, Johannes, Kropf, Siegfried, Sahm, Felix, Nakamura, Makoto, Mawrin, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
Basic and Translational Investigations
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5570238/
https://ncbi.nlm.nih.gov/pubmed/28482067
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nox018
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