The Checkpoint for Agonist Selection precedes Conventional Selection in Human Thymus

The thymus plays a central role in self-tolerance, in part by eliminating precursors with a T cell receptor (TCR) that binds strongly to self-antigens. However, the generation of self-agonist-selected lineages also relies on strong TCR signaling. How thymocytes discriminate between these opposite ou...

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Detalhes bibliográficos
Publicado no:Sci Immunol
Main Authors: Verstichel, Greet, Vermijlen, David, Martens, Liesbet, Goetgeluk, Glenn, Brouwer, Margreet, Thiault, Nicolas, Van Caeneghem, Yasmine, De Munter, Stijn, Weening, Karin, Bonte, Sarah, Leclercq, Georges, Taghon, Tom, Kerre, Tessa, Saeys, Yvan, Van Dorpe, Jo, Cheroutre, Hilde, Vandekerckhove, Bart
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569900/
https://ncbi.nlm.nih.gov/pubmed/28783686
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciimmunol.aah4232
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