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Disease associated anti-citrullinated protein memory B cells in rheumatoid arthritis persist in clinical remission

OBJECTIVE: In RA, autoreactive B cells are pathogenic drivers and sources of anti-citrullinated protein antibodies (ACPA) that serve as a diagnostic biomarker and predictor of worse long-term prognosis. Yet the immunobiologic significance of persistent ACPA production at a cellular level is poorly u...

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Detalhes bibliográficos
Publicado no:Arthritis Rheumatol
Main Authors: Pelzek, Adam J., Grönwall, Caroline, Rosenthal, Pamela, Greenberg, Jeffrey D., McGeachy, Mandy, Moreland, Larry, Rigby, William F.C., Silverman, Gregg J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569882/
https://ncbi.nlm.nih.gov/pubmed/28118534
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.40053
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