Development of a versatile and conventional technique for gene disruption in filamentous fungi based on CRISPR-Cas9 technology

Filamentous fungi represent an invaluable source of pharmaceutically active compounds. The development of versatile methods to genetically manipulate filamentous fungi is of great value for improving the low yields of bioactive metabolites and expanding chemical diversity. The CRISPR-Cas9-based syst...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Zheng, Yan-Mei, Lin, Fu-Long, Gao, Hao, Zou, Gen, Zhang, Jiang-Wei, Wang, Gao-Qian, Chen, Guo-Dong, Zhou, Zhi-Hua, Yao, Xin-Sheng, Hu, Dan
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569088/
https://ncbi.nlm.nih.gov/pubmed/28835711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-10052-3
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