Cutaneous pigmentation modulates skin sensitivity via tyrosinase-dependent dopaminergic signalling

We propose a new mechanism of sensory modulation through cutaneous dopaminergic signalling. We hypothesize that dopaminergic signalling contributes to differential cutaneous sensitivity in darker versus lighter pigmented humans and mouse strains. We show that thermal and mechanical cutaneous sensiti...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Ono, Kentaro, Viet, Chi T., Ye, Yi, Dang, Dongmin, Hitomi, Suzuro, Toyono, Takashi, Inenaga, Kiyotoshi, Dolan, John C., Schmidt, Brian L.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2017
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5569050/
https://ncbi.nlm.nih.gov/pubmed/28835637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09682-4
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