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Temporal Expression of Bim Limits the Development of Agonist-Selected Thymocytes and Skews Their TCRβ Repertoire

CD8αα TCRαβ(+) intestinal intraepithelial lymphocytes play a critical role in promoting intestinal homeostasis, although mechanisms controlling their development and peripheral homeostasis remain unclear. In this study, we examined the spatiotemporal role of Bim in the thymic selection of CD8αα prec...

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Detalhes bibliográficos
Publicado no:J Immunol
Main Authors: Li, Kun-Po, Fahnrich, Anke, Roy, Eron, Cuda, Carla M., Grimes, H. Leighton, Perlman, Harris R., Kalies, Kathrin, Hildeman, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568849/
https://ncbi.nlm.nih.gov/pubmed/27852740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1601200
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