Phosphatidylinositol 3'-kinase is activated by association with IRS-1 during insulin stimulation.

IRS-1 undergoes rapid tyrosine phosphorylation during insulin stimulation and forms a stable complex containing the 85 kDa subunit (p85) of the phosphatidylinositol (PtdIns) 3'-kinase, but p85 is not tyrosyl phosphorylated. IRS-1 contains nine tyrosine phosphorylation sites in YXXM (Tyr-Xxx-Xxx...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Backer, J M, Myers, M G, Shoelson, S E, Chin, D J, Sun, X J, Miralpeix, M, Hu, P, Margolis, B, Skolnik, E Y, Schlessinger, J
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 1992
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556882/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1380456/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05426.x
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