Andexanet Alfa for Acute Major Bleeding Associated with Factor Xa Inhibitors

BACKGROUND: Andexanet alfa (andexanet) is a recombinant modified human factor Xa decoy protein that has been shown to reverse the inhibition of factor Xa in healthy volunteers. METHODS: In this multicenter, prospective, open-label, single-group study, we evaluated 67 patients who had acute major ble...

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Veröffentlicht in:N Engl J Med
Hauptverfasser: Connolly, Stuart J., Milling, Truman J., Eikelboom, John W., Gibson, C. Michael, Curnutte, John T., Gold, Alex, Bronson, Michele D., Lu, Genmin, Conley, Pamela B., Verhamme, Peter, Schmidt, Jeannot, Middeldorp, Saskia, Cohen, Alexander T., Beyer-Westendorf, Jan, Albaladejo, Pierre, Lopez-Sendon, Jose, Goodman, Shelly, Leeds, Janet, Wiens, Brian L., Siegal, Deborah M., Zotova, Elena, Meeks, Brandi, Nakamya, Juliet, Lim, W. Ting, Crowther, Mark
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568772/
https://ncbi.nlm.nih.gov/pubmed/27573206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1056/NEJMoa1607887
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