An epitope-specific DerG-PG70 LEAPS vaccine modulates T cell responses and suppresses arthritis progression in two related murine models of rheumatoid arthritis

Rheumatoid arthritis (RA) is an autoimmune joint disease maintained by aberrant immune responses involving CD4+ T helper (Th)1 and Th17 cells. In this study, we tested the therapeutic efficacy of Ligand Epitope Antigen Presentation System (LEAPS™) vaccines in two Th1 cell-driven mouse models of RA,...

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Veröffentlicht in:Vaccine
Hauptverfasser: Mikecz, Katalin, Glant, Tibor T., Markovics, Adrienn, Rosenthal, Kenneth S., Kurko, Julia, Carambula, Roy E., Cress, Steve, Steiner, Harold L., Zimmerman, Daniel H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568759/
https://ncbi.nlm.nih.gov/pubmed/28583308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2017.05.009
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