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Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo.

Premature termination of transcription is assumed to be an important mechanism of c-myc regulation. Induction of terminal differentiation in the promyelocytic leukemia cell line HL60 by dimethyl-sulfoxide (DMSO) is accompanied by a block of RNA elongation within the first exon of the c-myc gene. We...

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Autori principali: Strobl, L J, Eick, D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 1992
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC556865/
https://ncbi.nlm.nih.gov/pubmed/1505520
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