Distinct aging profiles of CD8(+) T cells in blood versus gastrointestinal mucosal compartments

A hallmark of human immunosenescence is the accumulation of late-differentiated memory CD8(+) T cells with features of replicative senescence, such as inability to proliferate, absence of CD28 expression, shortened telomeres, loss of telomerase activity, enhanced activation, and increased secretion...

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Pubblicato in:PLoS One
Autori principali: Dock, Jeffrey, Ramirez, Christina M., Hultin, Lance, Hausner, Mary Ann, Hultin, Patricia, Elliott, Julie, Yang, Otto O., Anton, Peter A., Jamieson, Beth D., Effros, Rita B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568404/
https://ncbi.nlm.nih.gov/pubmed/28832609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0182498
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