High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

BACKGROUND: Alzheimer’s Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be caused by age-related failures to clear Aβ from the brain through pathways that involve the cerebrovasculature. Vascular risk factors are known to increase AD risk, but less is known...

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Publicado en:Mol Neurodegener
Main Authors: Robert, Jérôme, Button, Emily B., Stukas, Sophie, Boyce, Guilaine K., Gibbs, Ebrima, Cowan, Catherine M., Gilmour, Megan, Cheng, Wai Hang, Soo, Sonja K., Yuen, Brian, Bahrabadi, Arvin, Kang, Kevin, Kulic, Iva, Francis, Gordon, Cashman, Neil, Wellington, Cheryl L.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2017
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568306/
https://ncbi.nlm.nih.gov/pubmed/28830501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0201-0
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