High-density lipoproteins suppress Aβ-induced PBMC adhesion to human endothelial cells in bioengineered vessels and in monoculture

BACKGROUND: Alzheimer’s Disease (AD), characterized by accumulation of beta-amyloid (Aβ) plaques in the brain, can be caused by age-related failures to clear Aβ from the brain through pathways that involve the cerebrovasculature. Vascular risk factors are known to increase AD risk, but less is known...

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Pubblicato in:Mol Neurodegener
Autori principali: Robert, Jérôme, Button, Emily B., Stukas, Sophie, Boyce, Guilaine K., Gibbs, Ebrima, Cowan, Catherine M., Gilmour, Megan, Cheng, Wai Hang, Soo, Sonja K., Yuen, Brian, Bahrabadi, Arvin, Kang, Kevin, Kulic, Iva, Francis, Gordon, Cashman, Neil, Wellington, Cheryl L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568306/
https://ncbi.nlm.nih.gov/pubmed/28830501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-017-0201-0
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