JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation

BACKGROUND: We previously reported that JAK–STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we evaluated the efficacy of the JAK inhibitor tofacitinib (TOFA) for controlling IFN signalling via the JAK–STAT pathway and as a thera...

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Vydáno v:BMC Immunol
Hlavní autoři: Ikeda, Keigo, Hayakawa, Kunihiro, Fujishiro, Maki, Kawasaki, Mikiko, Hirai, Takuya, Tsushima, Hiroshi, Miyashita, Tomoko, Suzuki, Satoshi, Morimoto, Shinji, Tamura, Naoto, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568047/
https://ncbi.nlm.nih.gov/pubmed/28830352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-017-0225-9
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