JAK inhibitor has the amelioration effect in lupus-prone mice: the involvement of IFN signature gene downregulation

BACKGROUND: We previously reported that JAK–STAT-pathway mediated regulation of IFN-regulatory factor genes could play an important role in SLE pathogenesis. Here, we evaluated the efficacy of the JAK inhibitor tofacitinib (TOFA) for controlling IFN signalling via the JAK–STAT pathway and as a thera...

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Detalhes bibliográficos
Publicado no:BMC Immunol
Main Authors: Ikeda, Keigo, Hayakawa, Kunihiro, Fujishiro, Maki, Kawasaki, Mikiko, Hirai, Takuya, Tsushima, Hiroshi, Miyashita, Tomoko, Suzuki, Satoshi, Morimoto, Shinji, Tamura, Naoto, Takamori, Kenji, Ogawa, Hideoki, Sekigawa, Iwao
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5568047/
https://ncbi.nlm.nih.gov/pubmed/28830352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12865-017-0225-9
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