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scAAVIL-1ra dosing trial in a large animal model and validation of long-term expression with repeat administration for osteoarthritis therapy

A gene therapeutic approach to treat osteoarthritis (OA) appears to be on the horizon for millions of people who suffer from this disease. Previously we described optimization of a scAAVIL-1ra gene therapeutic vector and initially tested this in an equine model verifying long-term intrasynovial IL-1...

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Dettagli Bibliografici
Pubblicato in:Gene Ther
Autori principali: Goodrich, LR, Grieger, JC, Phillips, JN, Khan, N, Gray, SJ, McIlwraith, CW, Samulski, RJ
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567794/
https://ncbi.nlm.nih.gov/pubmed/25902762
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.21
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