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Activation of mammalian DNA ligase I through phosphorylation by casein kinase II.

Mammalian DNA ligase I has been shown to be a phosphoprotein. Dephosphorylation of purified DNA ligase I causes inactivation, an effect dependent on the presence of the N-terminal region of the protein. Expression of full-length human DNA ligase I in Escherichia coli yielded soluble but catalyticall...

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Udgivet i:EMBO J
Principais autores: Prigent, C, Lasko, D D, Kodama, K, Woodgett, J R, Lindahl, T
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556774/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1639065/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05362.x
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