The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity.

Protein tyrosine kinases participate in the transduction and modulation of signals that regulate proliferation and differentiation of cells. Excessive or deregulated protein tyrosine kinase activity can cause malignant transformation. The catalytic activity of the T cell protein tyrosine kinase p56l...

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Bibliographic Details
Published in:EMBO J
Main Authors: Bergman, M, Mustelin, T, Oetken, C, Partanen, J, Flint, N A, Amrein, K E, Autero, M, Burn, P, Alitalo, K
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 1992
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556773/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1639064/
https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05361.x
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