NKG2D signaling enhances Natural Killer cell responses but alone is insufficient to drive expansion during mouse cytomegalovirus infection

Natural killer (NK) cells play a critical role in host defense against viruses. Here, we investigated the role of NKG2D in the expansion of NK cells after mouse cytomegalovirus (MCMV) infection. Wild-type and NKG2D-deficient (Klrk1(−/−)) Ly49H(+) NK cells robustly proliferated when infected with MCM...

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Vydáno v:J Immunol
Hlavní autoři: Nabekura, Tsukasa, Gotthardt, Dagmar, Niizuma, Kouta, Trsan, Tihana, Jenus, Tina, Jonjic, Stipan, Lanier, Lewis L.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567695/
https://ncbi.nlm.nih.gov/pubmed/28760883
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1700799
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