Bridging Microscopic and Macroscopic Mechanisms of p53-MDM2 Binding with Kinetic Network Models

Under normal cellular conditions, the tumor suppressor protein p53 is kept at low levels in part due to ubiquitination by MDM2, a process initiated by binding of MDM2 to the intrinsically disordered transactivation domain (TAD) of p53. Many experimental and simulation studies suggest that disordered...

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Vydáno v:Biophys J
Hlavní autoři: Zhou, Guangfeng, Pantelopulos, George A., Mukherjee, Sudipto, Voelz, Vincent A.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Biophysical Society 2017
Témata:
Proteins
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567610/
https://ncbi.nlm.nih.gov/pubmed/28834715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2017.07.009
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