A carregar...
Markov models of the apo-MDM2 lid region reveal diffuse yet two-state binding dynamics and receptor poses for computational docking
MDM2 is a negative regulator of p53 activity and an important target for cancer therapeutics. The N-terminal lid region of MDM2 modulates interactions with p53 via competition for its binding cleft, exchanging slowly between docked and undocked conformations in the absence of p53. To better understa...
Na minha lista:
| Publicado no: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
|
| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4990920/ https://ncbi.nlm.nih.gov/pubmed/27538695 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep31631 |
| Tags: |
Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!
|