How Does the L884P Mutation Confer Resistance to Type-II Inhibitors of JAK2 Kinase: A Comprehensive Molecular Modeling Study

Janus kinase 2 (JAK2) has been regarded as an essential target for the treatment of myeloproliferative neoplasms (MPNs). BBT594 and CHZ868, Type-II inhibitors of JAK2, illustrate satisfactory efficacy in preclinical MPNs and acute lymphoblastic leukemia (ALL) models. However, the L884P mutation of J...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Kong, Xiaotian, Sun, Huiyong, Pan, Peichen, Li, Dan, Zhu, Feng, Chang, Shan, Xu, Lei, Li, Youyong, Hou, Tingjun
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567357/
https://ncbi.nlm.nih.gov/pubmed/28831147
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-09586-3
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