Efficient generation of bispecific IgG antibodies by split intein mediated protein trans-splicing system

Many methods have been developed to produce bispecific antibodies (BsAbs) for industrial application. However, huge challenges still remain in synthesizing whole length BsAbs, including their assembly, stability, immunogenicity, and pharmacodynamics. Here we present for first time a generic technolo...

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Bibliografiske detaljer
Udgivet i:Sci Rep
Main Authors: Han, Lei, Chen, Junsheng, Ding, Kai, Zong, Huifang, Xie, Yueqing, Jiang, Hua, Zhang, Baohong, Lu, Huili, Yin, Weihan, Gilly, John, Zhu, Jianwei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5567192/
https://ncbi.nlm.nih.gov/pubmed/28827777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-08641-3
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