Targeted degradation of the retinoblastoma protein by human papillomavirus E7-E6 fusion proteins.

The E6 and the E7 proteins of the oncogenic human papillomavirus types 16 and 18 can stably associate with p53 and the retinoblastoma protein, respectively. The E6-p53 interaction results in the accelerated degradation of p53 in vitro via the ubiquitin-dependent proteolysis system. In this study we...

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Pubblicato in:	EMBO J
Autori principali:	Scheffner, M, Münger, K, Huibregtse, J M, Howley, P M
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Publishing Group 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC556717/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1321031/ https://ncbi.nlm.nih.govhttps://doi.org/10.1002/j.1460-2075.1992.tb05307.x
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